Potential of Zinc-L-Selenomethionine to Improve the Health of Weaned Piglets and Its Antioxidant Stress Mechanism Through Modulation of PI3K/AKT and Nrf2/Keap1 Signaling Pathways
Shujie Liu, Yongming Li, Xin Tao, Siyuan Li, Jie Wu, Fei Ji, Ziwei Xu, Bo Deng
TL;DR
Zinc-L-selenomethionine improves the health of weaned piglets by reducing oxidative stress through specific molecular pathways.
Contribution
This study is the first to investigate the antioxidant mechanisms of Zn-L-SeMet in weaned piglets and intestinal cells.
Findings
Zn-L-SeMet improved growth, antioxidant function, and immune response in piglets.
Zn-L-SeMet reduced oxidative damage and apoptosis in intestinal cells.
Zn-L-SeMet activated PI3K/AKT and Nrf2/Keap1 signaling pathways.
Abstract
Zinc-L-selenomethionine (Zn-L-SeMet), a novel organic selenium (Se) source, shows great potential in alleviating oxidative stress. This study first evaluated the potential of Zn-L-SeMet to improve the health of weaned piglets and investigated underlying molecular mechanisms. In vivo, 240 weaned piglets were assigned to five dietary groups, namely, a control group (basal diet without Se) and four groups supplemented with Zn-L-SeMet (0.1, 0.2, 0.3, or 0.4 mg Se/kg in basal diet) for 42 days. In vitro, an oxidative stress model was established using hydrogen peroxide (H2O2) in porcine intestinal epithelial cells (IPEC-J2) to investigate the mechanisms of Zn-L-SeMet against oxidative damage. The results showed that Zn-L-SeMet improved growth performance, enhanced antioxidant and immune function, stimulated thyroid hormone secretion, and upregulated expression of selenoprotein genes. In…
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Taxonomy
TopicsSelenium in Biological Systems · Animal Nutrition and Physiology · Trace Elements in Health