Do Adjunctive Therapies with Natural Products Improve Periodontal Clinical Parameters After Non-Surgical Treatment? A Systematic Review and Meta-Analysis
Rafael Scaf de Molon, Joao Victor Soares Rodrigues, Erica Dorigatti de Avila, Davi da Silva Barbirato, Joao Pedro Franco Moura, Gabriele Vanzela Monteiro, Marcos Vinicius Alves, Leticia Helena Theodoro, Rolando Vernal, Wim Teughels
TL;DR
This study reviews and analyzes whether natural products used alongside standard treatment improve periodontal health outcomes.
Contribution
The paper provides a systematic review and meta-analysis of natural products as adjuncts to periodontal treatment.
Findings
Adjunctive natural products significantly improved probing pocket depth reduction and clinical attachment level gain.
Natural products also showed improvements in gingival inflammation and bleeding outcomes.
Substantial heterogeneity was observed among the studies included in the meta-analysis.
Abstract
Periodontitis is a highly prevalent chronic inflammatory disease initiated by dysbiotic biofilms and sustained by an exaggerated host immune response, for which scaling and root planing (SRP) remains the cornerstone of therapy. However, mechanical debridement alone may be insufficient to fully resolve inflammation in complex cases and in susceptible patients. In this context, natural products and host modulatory strategies have emerged as potential adjunctive therapies owing to their antimicrobial, anti-inflammatory, antioxidant, and immunomodulatory properties. This systematic review and meta-analysis aimed to evaluate the effectiveness of natural products used as adjuncts to SRP on periodontal clinical outcomes. Comprehensive electronic searches were conducted in MEDLINE/PubMed, Scopus, Web of Science, Cochrane CENTRAL, Embase, SciELO, and Google Scholar through December 2025, and…
Genes, proteins, chemicals, diseases, species, mutations and cell lines named across the full text — each resolved to its canonical identifier and authoritative record.
Click any figure to enlarge with its caption.
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Figure 6
Figure 7
Figure 8
Figure 9
Figure 10
Figure 11
Figure 12
Figure 13
Figure 14
Figure 15
Figure 16
Figure 17
Figure 18
Figure 19
Figure 20
Figure 21
Figure 22
Figure 23
Figure 24
Figure 25
Figure 26
Figure 27
Figure 28
Figure 29Peer Reviews
No public reviews on file for this paper yet. If you reviewed it on a platform where reviews are public (OpenReview, ICLR, NeurIPS, ICML), you can paste yours below so the community can read it here.
Videos
No videos yet. Explain this paper in a talk, walkthrough, or lecture? Add one.
Taxonomy
TopicsOral microbiology and periodontitis research · Endodontics and Root Canal Treatments · Oral and gingival health research