Green Synthesis of Au-Pd Bimetallic Nanoparticles Using Aspalathin and Their Toxicity Study
Naledi D. Seatle, Akeem O. Akinfenwa, Keenau M. Pearce, Idowu J. Sagbo, Mongi Benjeddou, Ahmed A. Hussein
TL;DR
This paper describes a green method to synthesize Au-Pd bimetallic nanoparticles using rooibos and aspalathin, and finds they are non-toxic and have potential biomedical uses.
Contribution
The novel use of pure aspalathin in green synthesis allows precise control over nanoparticle properties and improved cellular uptake.
Findings
Au-Pd nanoparticles synthesized with aspalathin form core–shell structures, while total extract forms alloys.
ASP-conjugated nanoparticles showed higher cellular uptake compared to total extract-based nanoparticles.
The nanoparticles exhibited no significant cytotoxicity, suggesting good biocompatibility for biomedical applications.
Abstract
Bimetallic nanoparticles have garnered significant attention in scientific literature due to their diverse applications and unique properties. Concurrently, green synthesis methodologies have emerged as environmentally friendly alternatives, reducing the ecological footprint of nanoparticle production. In this study, the efficient synthesis of Au-Pd bimetallic nanoparticles is presented, utilizing Aspalathus linearis (Burm.f.) R. Dahlgren, commonly known as green rooibos (GR), and its pure bioactive compound, Aspalathin (ASP). Integrating ASP as a pure compound into the green synthesis process offers precise control over nanoparticle characteristics, including size, morphology, and composition. Interestingly, the total extract forms an Au-Pd nanoparticle alloy, while aspalathin forms core–shell nanoparticles. Furthermore, cytotoxicity testing was carried out on selected cell lines to…
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Taxonomy
TopicsNanoparticles: synthesis and applications · Nanomaterials for catalytic reactions · Gold and Silver Nanoparticles Synthesis and Applications