Smart Magnetic Drug Delivery System for Targeted, Intracellular Delivery of Irinotecan and Platinum-Based Antitumoral Drugs
Ludmila Motelica, Bogdan Stefan Vasile, Denisa Ficai, Ovidiu-Cristian Oprea, Vasile-Adrian Surdu, Roxana Doina Trusca, Angela Spoiala, Geanina Voicu, Maria Anghelache, Daciana Silvia Marta, Victor-Eduard Peteu, Anton Ficai, Manuela Calin
TL;DR
This paper introduces a magnetic drug delivery system that improves targeted cancer treatment by delivering drugs directly into tumor cells and inducing cell death.
Contribution
The novel contribution is the functionalization of magnetic nanoparticles with glutamic acid and PEG for enhanced drug delivery and tumor cell internalization.
Findings
Functionalized magnetic nanoparticles with glutamic acid and PEG improve internalization into tumor cells.
Cisplatin-loaded nanoparticles showed the most effective results at a concentration of 0.1 mg/mL.
The system induces ferroptosis, an iron-dependent cell death process, in cancer cells.
Abstract
Coated magnetic nanoparticles (MNPs) comprising Fe3O4 are a powerful drug delivery system for cancer treatment. They can be preferentially internalized into the tumour cells and release the antitumoral agents on-site. In the present work, we have functionalized the MNPs with glutamic acid which, even if non-essential, is strongly involved in the protein synthesis as a nitrogen donor, being used as a conjugate for specific antitumoral drugs due to its capability to internalize into tumour versus healthy cells faster. The functionalized MNPs were stabilized by polyethylene glycol (PEG) coating. This system improves drug efficacy by concentrating therapeutic agents at the tumour site, and can also induce ferroptosis in cancer cells, an iron-dependent cell death process, which has a beneficial therapeutic effect. Additionally, PEG molecules on the surface of MNPs facilitate drug conjugation…
Genes, proteins, chemicals, diseases, species, mutations and cell lines named across the full text — each resolved to its canonical identifier and authoritative record.
Click any figure to enlarge with its caption.
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Figure 6
Figure 7
Figure 8
Figure 9
Figure 10
Figure 11
Figure 12
Figure 13
Figure 14
Figure 15
Figure 16
Figure 17
Figure 18
Figure 19
Figure 20
Figure 21
Figure 22
Figure 23
Figure 24
Figure 25Peer Reviews
No public reviews on file for this paper yet. If you reviewed it on a platform where reviews are public (OpenReview, ICLR, NeurIPS, ICML), you can paste yours below so the community can read it here.
Videos
No videos yet. Explain this paper in a talk, walkthrough, or lecture? Add one.
Taxonomy
TopicsNanoparticle-Based Drug Delivery · Nanoplatforms for cancer theranostics · Cancer Research and Treatment