New Strategies for the Prevention and Therapy of Alzheimer’s Disease Based on Stimulation of Brain Drainage and Lymphatic Clearance

TL;DR

This review explores new strategies for treating Alzheimer's disease by enhancing brain drainage and lymphatic clearance.

Contribution

The paper introduces innovative methods to stimulate meningeal lymphatic vessels for clearing brain waste products.

Findings

Noninvasive photobiomodulation can improve clearance of amyloid beta and cognitive function.

Stimulating lymphatic vessels may enhance anti-amyloid immunotherapy effectiveness.

Lifestyle factors like sleep and exercise support brain waste removal.

Abstract

Alzheimer’s disease (AD) is a serious medical challenge, representing an incurable and insidious disease. Current treatments can slow AD progression but cannot cure it. Promising new methods for AD therapy are essential for addressing the growing number of people with dementia, especially after the COVID-19 pandemic. The review highlights pioneering approaches to AD treatment based on innovative methods for the stimulation of brain drainage and clearance, in which the meningeal lymphatic vessels (MLVs) play a key role. Clinically promising noninvasive technologies using photobiomodulation for the effective clearance of metabolites, including amyloid beta (Aβ), and for the improvement of cognitive impairment during AD progression are discussed. An interesting part of the review is its analysis of innovative methods of improving the efficacy of anti-Aβ immunotherapy by stimulating MLV growth. The review is also focused on lifestyle, including sleep and physical exercises, discussing their support for the efficient lymphatic removal of waste products from the brain. Overall, the review provides an important, informative platform to excite the interest of a wide range of readers in the development of promising and clinically significant strategies for the treatment of AD, based on new strategies for the stimulation of brain drainage and clearance.

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