# A Case of Grade 2 Radiation‑Induced Osteosarcoma

**Authors:** Flore Brachotte, Matthieu Wendling

PMC · DOI: 10.5334/jbsr.4175 · 2026-03-12

## TL;DR

This case highlights the risk of developing osteosarcoma in areas previously exposed to radiation, even years later.

## Contribution

The paper presents a clinical case emphasizing the long-term risk of radiation-induced osteosarcoma.

## Key findings

- Radiation-induced osteosarcoma can occur years after initial treatment.
- Painful, ossifying masses in irradiated areas should raise suspicion for this condition.

## Abstract

Teaching point: The possibility of a radiation‑induced osteosarcoma should be considered in any painful, ossifying mass occurring within a previously irradiated area, even years after the initial treatment.

## Linked entities

- **Diseases:** osteosarcoma (MONDO:0002623)

## Full-text entities

- **Diseases:** Osteosarcoma (MESH:D012516), painful (MESH:D010146)

## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12985813/full.md

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Source: https://tomesphere.com/paper/PMC12985813