# New Insights into the Anti-Aging Mechanism of Collagen Peptides—Emphasis on Lysosomes and Mitochondria Function

## TL;DR

This paper reviews how collagen peptides may help delay skin aging by affecting lysosomes and mitochondria, suggesting new research directions for anti-aging therapies.

## Contribution

The paper highlights lysosomes and mitochondria as key organelles in collagen peptides' anti-aging effects, suggesting a shift from traditional pathways.

## Key findings

- Collagen peptides may delay skin aging by removing reactive oxygen species and inhibiting inflammation.
- Lysosomes and mitochondria are identified as key organelles in collagen peptides' anti-aging mechanisms.
- Current research should explore collagen peptides' effects beyond traditional signaling pathways like TGF-β/Smad.

## Abstract

With the intensification of social aging and the improvement of living standards, delaying aging has become a focus of common concern, especially in regard to skin aging. Although collagen peptides have been widely reported as therapeutic agents in relieving skin aging, the molecular mechanisms remain inadequately elucidated. This review emphasizes that the alleviation of skin aging by collagen peptides is a systematic and complex process, including the removal of reactive oxygen species, inhibition of inflammation, inhibition of extracellular matrix (ECM) degradation and melanin deposition, activation of lysosomal and mitochondrial function, and promotion of ECM synthesis. It also highlights that lysosomes and mitochondria may be the key organelles that regulate collagen peptides to alleviate skin aging. Current research on the mechanism of collagen peptides in alleviating skin aging still requires bold breakthroughs and should not be confined to the transforming growth factor (TGF-β)/Smad, mitogen-activated protein kinase, and nuclear factor kappa-B pathways. In addition, many natural antioxidant components have been proven to alleviate skin aging by regulating organelle function. Therefore, the regulatory effects of collagen peptides with antioxidant activity on mitochondrial and lysosome functions in aging skin need more attention and exploration, which is of great significance for further research on precise skin care and targeted anti-skin aging therapy.