# Plasma Bicarbonate as a Determinant of Fluid-Induced Acid–Base Changes in Postoperative Critically Ill Patients: A Retrospective Analysis

## TL;DR

This study shows that pre-infusion plasma bicarbonate levels influence how intravenous fluids affect acid-base balance in postoperative ICU patients.

## Contribution

The study demonstrates that individualized fluid selection based on baseline bicarbonate can better manage acid-base changes in ICU patients.

## Key findings

- Lower pre-infusion HCO3− levels correlate with greater acid-base changes after fluid infusion.
- Fluid-induced acid-base changes are strongly influenced by the difference between SIDINF and pre-infusion HCO3−.
- Higher infused volumes amplify acid-base changes when the SIDINF-HCO3− difference is large.

## Abstract

Background: Intravenous fluids modify acid–base balance by changing plasma strong ion difference (SIDPL) and total non-volatile weak acids. Experimental data suggest that pre-infusion plasma bicarbonate (HCO3−) may further modulate these effects. We tested this hypothesis in a large cohort of postoperative ICU patients receiving intravenous fluids. Methods: We retrospectively analyzed all-consecutive post-operative ICU admissions over a 21-month period who received fluid therapy. Fluid inputs/outputs, plasma electrolytes, and arterial blood gases were collected from admission to 9:00 A.M. of postoperative day one. Average SID of infused fluids (SIDINF) was calculated, and SIDPL and standard base excess variations (ΔSBE) were assessed. Patients were stratified by SIDINF tertiles (low, <41.0 mEq/L; medium, 41.2–54.6 mEq/L; high, ≥55.0 mEq/L), median pre-infusion HCO3− (24.3 [22.4–26.3] mmol/L), and tertiles of SIDINF-HCO3− difference. Results: Among 650 admissions, 641 were included (83% elective surgery). Pre-infusion acid–base was, as average, within normal ranges. Total infused volume averaged 2327 ± 1111 mL. Across SIDINF tertiles, ΔSBE increased from 1.2 ± 3.4 to 3.0 ± 3.0 and 3.4 ± 3.0 mmol/L (p < 0.001), paralleled by ΔSIDPL rise (0.6 ± 2.3, 1.3 ± 2.4 and 1.4 ± 2.3 mEq/L, respectively; p = 0.004). For any given SIDINF, patients with lower pre-infusion HCO3− showed greater ΔSBE and ΔSIDPL (p < 0.001). When analyzed by tertiles of SIDINF-HCO3− difference, ΔSBE rose from 1.0 ± 3.2 to 2.7 ± 2.9 and 4.0 ± 3.0 mmol/L (p < 0.001), with amplified effects at higher infused volume (>2500 mL). Conclusions: In postoperative ICU patients, fluid-induced acid–base changes are largely driven by SIDINF-HCO3− difference, supporting individualized fluid selection based on baseline HCO3−.