# Regenesis: Repair and regeneration reinvented in stem cell therapeutics

**Authors:** Hitesh Chopra, Yuanyuan Han

PMC · DOI: 10.1016/j.stemcr.2026.102825 · Stem Cell Reports · 2026-02-26

## TL;DR

The paper introduces 'regenesis' as a new concept to better describe outcomes in stem cell therapies.

## Contribution

The novel contribution is proposing 'regenesis' to bridge the gap in current terminology for stem cell-mediated tissue outcomes.

## Key findings

- Current terminology fails to capture most stem cell-mediated outcomes.
- The concept of 'regenesis' is introduced to describe hybrid tissue outcomes.
- The paper aims to stimulate discussion on updating terminology in the field.

## Abstract

Despite rapid advancements in stem cell-based therapies, the repair-regeneration dichotomy often fails to capture most stem cell-mediated outcomes. We propose “regenesis” as an integrative framework describing hybrid tissue outcomes. This commentary highlights the conceptual gap and aims to stimulate discussion on updating terminology in stem cell therapeutics.

## Full-text entities

- **Diseases:** Bone defects (MESH:D001847), Cardiac injuries (MESH:D006331), myocardial infarction (MESH:D009203), fibrosis (MESH:D005355)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

_Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC12985373/full.md

## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12985373/full.md

## References

12 references — full list in the complete paper: https://tomesphere.com/paper/PMC12985373/full.md

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Source: https://tomesphere.com/paper/PMC12985373