# Diagnostic Value of miR-21, miR-122, miR-145, and miR-146a in Acute Pancreatitis: Findings from the PASEVO Cohort in Southeastern Romania

## TL;DR

This study explores the potential of specific miRNAs as diagnostic markers for acute pancreatitis in a Romanian cohort.

## Contribution

The study evaluates the diagnostic value of miR-21, miR-122, miR-145, and miR-146a in acute pancreatitis severity assessment.

## Key findings

- Altered miRNA levels correlate with AP severity and disease progression.
- miR-21, miR-122, miR-145, and miR-146a show potential as non-invasive biomarkers for AP.
- miRNA profiling could improve early diagnosis and risk stratification in AP patients.

## Abstract

Acute pancreatitis (AP) is an inflammatory condition of the pancreas that initiates a cascade of inflammation, which can cause pancreatic damage or spread to other organs. The severity of AP ranges from mild acute pancreatitis (MAP) to severe acute pancreatitis (SAP). While standard diagnostic tools include contrast-enhanced CT scans, clinical scoring systems like APACHE II and Ranson, and laboratory tests, miRNAs have emerged as crucial regulators of gene expression involved in various physiological and pathological processes. Over the last decade, research has demonstrated that significant alterations in miRNA levels are integral to AP development. Since one miRNA can target multiple genes, they serve as key modulators of disease progression.