# GDF15 in Patients with Autoimmune Primary Adrenal Insufficiency

## TL;DR

This study found that patients with autoimmune primary adrenal insufficiency have higher levels of GDF15, a stress-related protein, compared to healthy individuals.

## Contribution

The study identifies elevated GDF15 levels in autoimmune primary adrenal insufficiency and their associations with clinical parameters.

## Key findings

- Patients with PAI had significantly higher GDF15 levels than healthy controls.
- GDF15 levels in PAI patients correlated with age, disease duration, and body composition metrics.
- GDF15 showed negative correlations with DHEAS and sex hormone levels in PAI patients.

## Abstract

Growth differentiation factor 15 (GDF15) is a stress-response protein that conveys cellular distress signals to the brain and activates neural pathways leading to weight loss. GDF15 levels are increased in glucocorticoid deficiency; however, multiple factors may influence its levels in patients with primary adrenal insufficiency (PAI). The objective of this study was to determine circulating GDF15 levels in patients with PAI compared with a control group and to assess their associations with other clinical parameters. We included 37 patients (22 females) with autoimmune PAI and 47 healthy controls. Serum GDF15 levels, together with anthropometrical, hormonal and biochemical parameters, were assessed. Patients with PAI had significantly higher circulating GDF15 levels than controls did (1276.8 ± 952.1 vs. 682.8 ± 270.2 pg/mL, p < 0.001). In both groups, GDF15 levels were positively correlated with age (p < 0.001). In patients with PAI, GDF15 showed positive correlations with disease duration and duration of autoimmune thyroid disease, gonadotropin levels, waist-to-hip ratio, and body fat percentage, and negative correlations with DHEAS and sex hormone levels. In conclusion, GDF15 levels are increased in patients with PAI compared with healthy controls and correlate with age and the duration of autoimmune disease.