# The Impact of Sociodemographic Disparities on Health-Related Quality of Life for Adults with Gliomas

**Authors:** Michael A. Perez, Devon C. Riegel, Joshua Amit Budhu

PMC · DOI: 10.3390/cancers18050718 · Cancers · 2026-02-24

## TL;DR

This paper explores how gliomas and their treatments affect patients' quality of life, emphasizing the role of sociodemographic disparities and suggesting ways to improve outcomes.

## Contribution

The paper highlights sociodemographic disparities in health-related quality of life for glioma patients and identifies areas for innovation.

## Key findings

- Gliomas impact multiple domains of health-related quality of life, including physical, cognitive, and emotional functioning.
- Sociodemographic disparities contribute to inequities in health-related quality of life for glioma patients.
- There are opportunities to improve outcomes through clinical care and policy approaches.

## Abstract

This article reviews the impact of glioma diagnoses and treatments on patients’ quality of life. Because gliomas affect the brain, they can influence physical, cognitive, emotional, and social functioning in ways that extend beyond traditional clinical outcomes. Using the World Health Organization’s health-related quality-of-life framework, this review examines the multiple domains of life affected by gliomas and highlights opportunities to improve patient-centered outcomes through clinical care, care delivery, and broader health system and policy approaches.

Health-related quality of life is a multidimensional concept used to describe one’s well-being in relation to their disease. Individuals with gliomas, the most commonly occurring malignant primary brain tumor, experience a multitude of symptoms due to their disease and treatments. Using the World Health Organization’s health-related quality-of-life model, we review the impact of this disease across each domain of the model. Furthermore, we summarize known sociodemographic disparities that contribute to inequities in health-related quality of life and highlight areas that require further investigation. Finally, we discuss potential areas for innovation to better address current gaps and inequities affecting the health-related quality of life of individuals with gliomas.

## Full-text entities

- **Diseases:** Gliomas (MESH:D005910), brain tumor (MESH:D001932)

## Full text

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## Figures

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## References

109 references — full list in the complete paper: https://tomesphere.com/paper/PMC12984654/full.md

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Source: https://tomesphere.com/paper/PMC12984654