Beyond Epilepsy Control: Repurposing Antiepileptic Drugs in Central Nervous System Tumor Therapy
Haochen Zhao, Qian Jiang, Quanji Wang, Zihan Wang, Yimin Huang, Ting Lei
TL;DR
This review explores how antiepileptic drugs, traditionally used for seizures, may also help treat central nervous system tumors by targeting multiple tumor-related pathways.
Contribution
The paper introduces the novel concept of repurposing antiepileptic drugs for CNS tumor therapy through multitarget mechanisms.
Findings
Classic and novel AEDs show antitumor activity through metabolic reprogramming and epigenetic regulation.
AEDs influence the tumor immune microenvironment and endoplasmic reticulum stress pathways.
These drugs offer a theoretical basis for multitarget therapeutic strategies in CNS tumors.
Abstract
Antiepileptic drugs (AEDs) are primarily indicated for controlling epileptic seizures. However, accumulating clinical evidence suggests that their benefits in patients with central nervous system (CNS) tumors extend beyond seizure management. Emerging evidence indicates that AEDs possess direct antitumor activity independent of their antiepileptic effects, highlighting a promising novel direction for CNS tumor therapy. This review elucidates the multifaceted antitumor mechanisms of classic (e.g., valproic acid and levetiracetam) and novel (e.g., cannabidiol) AEDs, including their impacts on metabolic reprogramming, epigenetic regulation, endoplasmic reticulum stress and unfolded protein response (ERS-UPR), ion homeostasis, and the tumor immune microenvironment (TIME) to provide new insights and a theoretical basis for developing multitarget therapeutic strategies.
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Taxonomy
TopicsEndoplasmic Reticulum Stress and Disease · Pharmacological Receptor Mechanisms and Effects · Autophagy in Disease and Therapy