# Artificial intelligence-driven peptide blocks gasdermin pyroptosis and alleviates inflammation

**Authors:** Mingsheng Liu, Hongqing Zhou, Min Wu

PMC · DOI: 10.1093/pcmedi/pbag004 · 2026-03-10

## Full-text entities

- **Genes:** GSDMC (gasdermin C) [NCBI Gene 56169] {aka MLZE}, CASP1 (caspase 1) [NCBI Gene 834] {aka ICE, IL1BC, P45}, FCGRT (Fc gamma receptor and transporter) [NCBI Gene 2217] {aka FCRN, FcgammaRn, alpha-chain}, CMPK1 (cytidine/uridine monophosphate kinase 1) [NCBI Gene 51727] {aka CK, CMK, CMPK, UMK, UMP-CMPK, UMPK}, IL1B (interleukin 1 beta) [NCBI Gene 3553] {aka IL-1, IL1-BETA, IL1F2, IL1beta}, GSDMD (gasdermin D) [NCBI Gene 79792] {aka DF5L, DFNA5L, FKSG10, GSDMDC1}, ALB (albumin) [NCBI Gene 213] {aka FDAHT, HSA, PRO0883, PRO0903, PRO1341}, NLRP3 (NLR family pyrin domain containing 3) [NCBI Gene 114548] {aka AGTAVPRL, AII, AVP, C1orf7, CIAS1, CLR1.1}, SLC17A5 (solute carrier family 17 member 5) [NCBI Gene 26503] {aka AST, ISSD, NSD, SD, SIALIN, SIASD}, IL18 (interleukin 18) [NCBI Gene 3606] {aka IGIF, IL-18, IL-1g, IL1F4}
- **Diseases:** inflammation (MESH:D007249), mitochondrial (MESH:D028361), multi-organ damage (MESH:D000092124), sepsis (MESH:D018805), autoimmune disorders (MESH:D001327), infections (MESH:D007239), organ injury (MESH:D009102)
- **Chemicals:** lipid (MESH:D008055), nigericin (MESH:D009550), LPS (MESH:D008070), ATP (MESH:D000255), disulfiram (MESH:D004221), polyethylene glycol (MESH:D011092), phospholipid (MESH:D010743), reactive oxygen species (MESH:D017382), PDA hydrogel (-)
- **Species:** Homo sapiens (human, species) [taxon 9606], Mus musculus (house mouse, species) [taxon 10090]
- **Cell lines:** THP-1 — Homo sapiens (Human), Childhood acute monocytic leukemia, Cancer cell line (CVCL_0006)

## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC12983214/full.md

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Source: https://tomesphere.com/paper/PMC12983214