# Antioxidant properties of nano-formulated carotenoids and natural phenolic compounds against oxidative stress-induced health diseases

## TL;DR

This paper reviews how nanoencapsulated natural antioxidants can help combat oxidative stress and related diseases by improving their stability and bioavailability.

## Contribution

The paper highlights recent advances in using nano-delivery systems to enhance the effectiveness of natural antioxidants against oxidative stress.

## Key findings

- Nanoencapsulation improves the stability and bioavailability of natural antioxidants.
- Phytoantioxidant-based nano-delivery systems show potential in reducing oxidative damage linked to aging and disease.
- Recent studies demonstrate the effectiveness of nano-formulated carotenoids and phenolic compounds in combating lipid peroxidation.

## Abstract

Radical oxygen species formed in human tissue cells via many endogenous and exogenous pathways cause extensive oxidative damage which has been linked to various human diseases. This investigation focused on the antioxidant potential of nano-carriers loaded with dietary natural antioxidants as phytotherapeutic agents. Main aim of this scientific review is to update the most recent advances in the application of nanoencapsulation to natural antioxidants against aging-related oxidative stress and associated pathological conditions. It provides an overview of recent in vitro and vivo trials on the potential of several nanoencapsulated antioxidant compounds (such as carotenoids, tocopherols, flavonoids and phenolic acids) to retard oxidative changes linked to carcinogenesis, cardiovascular and other serious health damages.

Lipid peroxidation -through the formation of reactive oxygen species (ROS)- is a very harmful biological process that links to the development of many adverse effects for the human health (including cardiovascular diseases and carcinogenesis) Over the last decade, an increasing body of literature evidence has demonstrated the beneficial in vivo antioxidant properties of many phytochemicals (such as dietary carotenoids and phenolic compounds) against lipid peroxidation by trapping the chain reaction of free radicals in human organism.

However, the administration of natural antioxidants is very challenging due to instability, low bio-accessibility, and limited bioavailability. A recent body of literature has focused on the rapidly developed Nanoscience and Nanomedicine applications that offer efficient solutions against this technological and health related challenge.

This manuscript focuses on the antioxidant potential of various nano-carriers loaded with phytotherapeutic agents. The aim of this review is to update on the recent advances in the application of phytoantioxidant-based nano-delivery systems to combat the aging-related oxidative stress and associated pathological conditions.