# Donor sperm IVF pregnancies exhibit elevated risk of new-onset hypertensive disorders: a retrospective cohort study

## TL;DR

Using donor sperm in IVF increases the risk of developing pregnancy-related high blood pressure disorders compared to using a partner's sperm.

## Contribution

This study identifies donor sperm use as an independent risk factor for new-onset hypertensive disorders in IVF pregnancies.

## Key findings

- The incidence of new-onset HDP was 2.7% in DS-IVF and 1.6% in PS-IVF.
- Donor sperm use was an independent risk factor for HDP (OR, 2.063).
- Twin pregnancy and elevated BMI were also significant risk factors in both groups.

## Abstract

To evaluate the incidence of new-onset Hypertensive Disorders of Pregnancy (HDP) in donor sperm IVF (DS-IVF) compared with partner sperm IVF (PS-IVF) pregnancies.

We retrospectively analyzed a total of 855 DS-IVF cycles and 4,816 PS-IVF cycles of pregnancies delivering after 20 weeks’ gestation achieved live birth between January 2010 and December 2022. All patients underwent fresh embryo transfer after oocyte retrieval. The incidence of new-onset HDP was compared between the two groups.

The overall incidence of new-onset HDP was 1.7%, with rates of 2.7% in DS-IVF group and 1.6% in PS-IVF group. Multivariate Analysis of risk factors in the entire cohort identified twin pregnancy (OR, 2.483: 95%CI: 1.649–3.739, P < 0.001), elevated body mass index (BMI) (OR, 1.150: 95%CI: 1.095–1.209, P < 0.001), and the use of donor sperm (OR, 2.063: 95%CI: 1.229–3.463, P = 0.006) as independent risk factors for new-onset HDP. In subgroup analyses of both DS-IVF and PS-IVF cohorts, twin pregnancy [DS-IVF: OR, 2.575: 95%CI: 1.085–6.115, P = 0.032; PS-IVF: OR, 2.454: 95%CI: 1.542–3.906, p < 0.001] and elevated BMI [DS-IVF: OR, 1.152: 95%CI: 1.026–1.292, P = 0.016; PS-IVF: OR, 1.150: 95%CI: 1.089–1.215, p < 0.001] were identified as independent risk factors for new-onset HDP.

The use of donor sperm is an independent risk factor for new-onset HDP in IVF-conceived pregnancies.