# Nanotechnology-enabled delivery of luteolin: a comprehensive review on multidisease therapeutic applications

## TL;DR

This paper reviews how nanotechnology improves luteolin's effectiveness for treating various diseases by overcoming its low bioavailability.

## Contribution

The paper provides a comprehensive review of luteolin nanocomposites for multidisease therapeutic applications.

## Key findings

- Luteolin nanocomposites show improved drug delivery and therapeutic effects.
- They are effective in treating cancer, diabetes, and cardiovascular diseases.
- Nanotechnology enhances luteolin's bioavailability and clinical potential.

## Abstract

Luteolin is a natural flavonoid compound widely found in various plants, known for its antioxidant, anti-inflammatory, cardiovascular protective and anti-tumor activities. However, its low bioavailability due to rapid metabolism and low solubility hinders its clinical application. In recent years, with the development of nanotechnology, luteolin combined with nanomaterials to form nanocomposites has shown promising drug delivery performance and therapeutic effects in numerous diseases. This article reviews the latest research progress on luteolin nanocomposites in disease treatment, exploring their potential applications in cancer, diabetes, cardiovascular diseases, neurological disorders, and other conditions.