# Transcranial stimulation as a possible therapeutic proposal in long COVID

**Authors:** Lidiane Palheta Miranda dos Santos, Julliana Vieira Leão, Ketelen Yasmim Braga de Moraes Silva, Danilo Lameira dos Santos, Chrisllane Nascimento Batista, Jonna Almeida Barros, Alna Carolina Mendes Paranhos, Ápio Ricardo Nazareth Dias, Luiz Fábio Magno Falcão

PMC · DOI: 10.3389/fresc.2026.1766757 · 2026-02-27

## TL;DR

This paper explores the potential of transcranial stimulation as a treatment for long COVID's neurological symptoms.

## Contribution

It critically reviews current evidence on neuromodulation for managing long COVID symptoms.

## Key findings

- Neuromodulation shows promise for treating refractory neurological symptoms in long COVID.
- Transcranial stimulation could offer new therapeutic perspectives for affected individuals.

## Abstract

The COVID-19 pandemic triggered an unprecedented global health crisis, with significant repercussions on the mental and neurological health of millions of individuals. Long COVID, characterized by persistent and debilitating symptoms, including chronic fatigue, pain, cognitive impairment, and mood swings, represents a substantial therapeutic challenge. In this context, neuromodulation emerges as a promising therapeutic strategy, offering new perspectives for the management of refractory neurological symptoms. This article aims to critically review the current evidence on the use of neuromodulation in patients with long COVID.

## Full-text entities

- **Diseases:** chronic fatigue (MESH:D015673), cognitive impairment (MESH:D003072), Long COVID (MESH:D000094024), pain (MESH:D010146), COVID-19 (MESH:D000086382)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC12982166/full.md

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Source: https://tomesphere.com/paper/PMC12982166