# Complete genome sequences of Staphylococcus aureus isolates with a novel sequence type from a patient with hospital-acquired pneumonia

**Authors:** Daniel B. Amusin, Sophia H. Nozick, Richard G. Wunderink, Egon A. Ozer, Alan R. Hauser

PMC · DOI: 10.1128/mra.01282-25 · 2026-01-28

## TL;DR

Researchers sequenced the genome of a Staphylococcus aureus isolate from a patient with hospital-acquired pneumonia and identified a novel sequence type.

## Contribution

The study reports a novel sequence type (ST10248) of Staphylococcus aureus isolated from a hospital-acquired pneumonia case.

## Key findings

- The genome of the isolate was found to be 2.74 Mb in size.
- The genome encodes 2,658 genes and represents a new sequence type, ST10248.

## Abstract

The complete genome of a Staphylococcus aureus isolate causing hospital-acquired pneumonia was sequenced. Genetic changes in subsequent isolates (cultured 8, 20, and 22 days later) from the lungs of the patient were identified. The genome comprised a 2.74 Mb chromosome encoding 2,658 genes, representing a novel sequence type designated ST10248.

## Linked entities

- **Species:** Staphylococcus aureus (taxon 1280)

## Full-text entities

- **Diseases:** pneumonia (MESH:D011014)
- **Species:** Homo sapiens (human, species) [taxon 9606], Staphylococcus aureus (species) [taxon 1280]

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Source: https://tomesphere.com/paper/PMC12981102