# Draft genomes of four multidrug-resistant (MDR) Gammaproteobacteria from biofilm on hemodialysis catheters in Gujarat, India

**Authors:** Rajsekhar Adhikary, Sayan Poddar, Dhara Patel, Tanmoy Sen, Sishir Gang, Debarati Chattopadhyay, Uttam Kumar Nath, Saugata Hazra

PMC · DOI: 10.1128/mra.00979-25 · 2026-01-28

## TL;DR

This study reports the draft genomes of four antibiotic-resistant bacteria isolated from hemodialysis catheters in Gujarat, India.

## Contribution

The paper provides new genomic insights into multidrug-resistant Gammaproteobacteria from clinical biofilms.

## Key findings

- Four Gram-negative bacteria with antibiotic resistance were isolated from catheter biofilms.
- Whole-genome analysis revealed multiple antibiotic-resistant gene cassettes in these bacteria.

## Abstract

Four Gram-negative bacteria, viz. Pseudomonas aeruginosa HL_CHRF_S30, Klebsiella quasipneumoniae HL_CHRU_S36A, Enterobacter bugandensis HL_CHRU_S49, and Acinetobacter haemolyticus HL_CHRU_S74 were isolated from the biofilm of the catheter tip of 152 renal failure patients. Multiple antibiotic-resistant gene cassettes were predicted by whole-genome analysis of these Gammaproteobacteria to develop antibiotic resistance.

## Linked entities

- **Diseases:** renal failure (MONDO:0001106)
- **Species:** Pseudomonas aeruginosa (taxon 287), Klebsiella quasipneumoniae (taxon 1463165), Enterobacter bugandensis (taxon 881260), Acinetobacter haemolyticus (taxon 29430)

## Full-text entities

- **Diseases:** renal failure (MESH:D051437)
- **Species:** Klebsiella quasipneumoniae (species) [taxon 1463165], Homo sapiens (human, species) [taxon 9606], Pseudomonas aeruginosa (species) [taxon 287], Bacteria Latreille et al. 1825 (Bacteria stick insect, genus) [taxon 629395], Acinetobacter haemolyticus (species) [taxon 29430], Enterobacter bugandensis (species) [taxon 881260]
- **Mutations:** S36A

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Source: https://tomesphere.com/paper/PMC12981050