# Cytotoxic, Genotoxic, and Mutagenic Effects of Organotellurane RF07 in Female Swiss Mice (Mus musculus)

## TL;DR

This study investigates the toxic effects of an organotellurane compound in female mice, revealing DNA damage and other harmful impacts.

## Contribution

This is the first study to explore the cytotoxic, genotoxic, and mutagenic effects of RF07 in mice.

## Key findings

- RF07 increased DNA damage and clastogenic/aneugenic effects in mice.
- The compound caused cytotoxicity in bone marrow erythroid precursors and myelosuppression.
- RF07 also induced hepatotoxicity and altered erythrocyte ratios.

## Abstract

The organotellurane RF07 (RF07) is an organic compound containing tellurium, a rare semi‐metal, and its leishmanicidal and antimalarial activity has already been reported in previous studies. This study evaluated the toxic effects of RF07 at 0.42, 21.37, and 42.75 mg/kg using comet assay, micronucleus test, and hematological/biochemical tests in Mus musculus. Female Swiss mice received intraperitoneal RF07. Blood was collected at 24, 48, and 72 h, followed by euthanasia for bone marrow analysis. Results showed RF07 increased DNA damage, clastogenic/aneugenic effects via micronuclei formation, and cytotoxicity through apoptosis in bone marrow erythroid precursors and altering the ratio of polychromatic to normochromatic erythrocytes. RF07 also caused myelosuppression and hepatotoxicity. To our knowledge, this is the first study explore these toxic effects. However, the mechanism remains unclear, requiring further investigation.