# Regenerative Synergy in Facial Rejuvenation: A Pilot Clinical Study of Polydioxanone Microspheres (Ultra V® UltraCol 200), Organic Silicon, and Adipostructuring

## TL;DR

This pilot study explores a combination of PDO microspheres, organic silicon, and a specific injection technique to improve facial rejuvenation in older patients.

## Contribution

The study introduces a novel combination of PDO microspheres and organic silicon using adipostructuring for facial rejuvenation.

## Key findings

- Notable improvements in facial tridimensionality and volumetric projection were observed.
- Reduction in nasolabial fold depth and enhanced malar region positioning were reported.
- The treatment was deemed safe and effective for older patients.

## Abstract

Background

Dermal fillers used with minimally invasive techniques have currently achieved an important role in regenerative medicine and in alleviating skin damage over the years.

Objectives

To evaluate clinical results after the use of the Polydioxanone Collagen Biostimulator Ultra V® UltraCol 200 (Ultracol), commonly referred to as PDO microspheres, with the addition of organic silicon to enhance Ultracol biostimulation, using the adipostructuring technique in a group of older patients who consulted to improve the quality of their skin.

Materials and methods

The study included 20 patients (3 men and 17 women), aged 40 to 80 years. We used Ultracol plus organic silicon. Injections were performed using the facial adipostructuring technique, with a 22-gauge, 50-mm cannula, injecting 2.5 mL per hemiface in a single session. We evaluated results at 10 days and 2 months after the procedure using photography and parameters selected by a blinded evaluator, along with a satisfaction survey.

Results

Clinical evaluation demonstrated noticeable improvement in facial tridimensionality, with enhanced volumetric projection and contour definition. A reduction in nasolabial fold depth was observed, along with improved vertical positioning of the malar region. Additionally, better definition of the infraorbital area was noted, accompanied by a subtle increase in supraperiosteal volume. Overall, these changes were considered favorable outcomes in this treated older patient group.

Conclusion

Ultracol plus organic silicon, using the facial adipostructuring technique in a group of older patients, can be considered a suitable and safe therapeutic alternative.