# glorund functions in the Drosophila intestine to regulate triglyceride storage and the expression of lipid transport protein genes

## TL;DR

This study shows that the Drosophila gene glorund helps regulate fat storage and lipid transport in the intestine.

## Contribution

The novel finding is that glo functions in the intestine to control lipid transport and fat storage.

## Key findings

- Reducing glo in intestines increases whole animal triglyceride storage.
- Lower glo levels decrease expression of lipid transport protein genes.
- Glo regulates lipid transport and organismal fat storage in Drosophila.

## Abstract

The intestine acts as the primary site for absorption of dietary lipids. These lipids are packaged and transported via lipoprotein complexes, whose altered levels correlate with metabolic disease.  The
Drosophila
splicing factor glorund (glo) has been shown to affect the expression of apoB-family lipoproteins, including microsomal triacylglycerol transfer protein, lipid transfer particle, and lipophorin, in the fly adipose tissue. Here, we demonstrate that decreasing
glo
in intestines leads to increased whole animal triglyceride storage, but decreased expression of lipid transport protein genes. Together, these data suggest that glo functions in the intestine to regulate lipid transport and organismal fat storage.