# Investigate the effect of oxygen-driven salbutamol combined with methylprednisolone on bronchial asthma from the perspective of serum molecular markers

## TL;DR

This study finds that using oxygen-driven salbutamol with methylprednisolone improves asthma outcomes in children by reducing inflammation and stress markers.

## Contribution

The novel contribution is evaluating oxygen-driven salbutamol combined with methylprednisolone through serum molecular markers in pediatric asthma.

## Key findings

- Oxygen-driven salbutamol plus methylprednisolone improved pulmonary ventilation and reduced inflammatory markers in children with asthma.
- The treatment combination increased antioxidant levels and improved immune function compared to standard treatment.
- Significant decreases in stress response indicators and IgE were observed in the oxygen-driven treatment group.

## Abstract

This study explores the application of oxygen-driven salbutamol (SA) combined with methylprednisolone (MP) in bronchial asthma (BA) from the perspective of objective clinical markers, including serum inflammatory response, oxidative stress response, immunoglobulin, and pulmonary ventilation function.

A retrospective analysis was performed on 207 pediatric BA patients admitted to our hospital between January 2022 and January 2025. Of them, 114 children received MP combined with SA nebulization (control group), and 93 children received MP combined with oxygen-driven SA (observation group). The pulmonary ventilation function, inflammatory mediators (HIF-1a, IL-4, IL-6, IL-8 and TNF-a), stress response indicators (SOD, NO, ET-1 and MDA) and immunoglobulin (IgE, IgA, IgM and IgG) were detected and compared before and after treatment.

Post-treatment, the observation group demonstrated superior pulmonary ventilation function and significantly lower levels of inflammatory mediators (HIF-1a, IL-4, IL-6, IL-8, and TNF-a) compared to the control group (P < 0.05). Regarding stress response, the SOD level in the observation group was higher after treatment, while the levels of NO, ET-1, and MDA were lower (P < 0.05). In addition, IgE was lower and IgA was higher in the observation group than in the control group after treatment (P < 0.05).

The combination of oxygen-driven SA and MP is more effective in mitigating inflammatory, stress responses and optimizing immune function in pediatric BA patients.