# RNA editing in cardiovascular health and disease

## TL;DR

This review explains how RNA editing affects heart health and disease, highlighting its role in development and potential for treatment.

## Contribution

The paper reviews recent findings on A-to-I RNA editing's role in cardiovascular biology and its therapeutic potential.

## Key findings

- A-to-I RNA editing is essential for normal cardiovascular development and function.
- Aberrant RNA editing contributes to the progression of cardiovascular diseases.
- RNA editing could be harnessed as a biomarker and therapeutic target for cardiovascular conditions.

## Abstract

Post-transcriptional RNA modifications can alter RNA structure, stability, localization, and function. Adenosine-to-inosine (A-to-I) RNA editing is a post-transcriptional modification that converts adenosine nucleotides in RNA to inosine nucleotides, catalyzed by adenosine-deaminase-acting-on-RNA (ADAR) enzymes. Recent studies have shown that A-to-I RNA editing is required for cardiovascular development and homeostasis whilst aberrant RNA editing plays a role in cardiovascular diseases. This article provides an overview of A-to-I RNA editing events that have been implicated in cardiovascular biology and disease. It also discusses harnessing RNA editing for cardiovascular disease biomarker development and engineering RNA editing for cardiovascular disease treatment.

This review summarizes reported findings showing that adenosine-to-inosine RNA editing is important for cardiovascular development and homeostasis, while aberrant editing is associated with cardiovascular diseases.