# Epicardial adipose tissue radiomic features from pre-procedural CT to predict atrial fibrillation recurrence after catheter ablation for pulmonary vein isolation

## TL;DR

This study uses CT scans and machine learning to predict if atrial fibrillation will return after a heart procedure, combining fat tissue features and clinical data.

## Contribution

A novel fusion model integrating EAT radiomics and clinical variables for predicting AF recurrence after PVI.

## Key findings

- The fusion model achieved an AUC of 0.81 for predicting AF recurrence.
- Texture heterogeneity in EAT and NT-proBNP were key predictive features.
- Ensemble methods outperformed other models in predicting recurrence.

## Abstract

This study aimed to develop and validate a machine learning model that integrates radiomic features of epicardial adipose tissue (EAT) from pre-procedural CT angiography with clinical variables to predict atrial fibrillation (AF) recurrence after pulmonary vein isolation (PVI).

This retrospective study initially included 1,551 AF patients who underwent PVI. After data integrity screening and 1:1 propensity score matching (PSM) to balance confounding factors, the final analysis cohort consisted of 302 patients (151 with recurrence and 151 without recurrence). EAT was segmented from preoperative CT angiography images using a SwinUNETR model, which was pre-trained via transfer learning on manually annotated images. Following segmentation, radiomic features were extracted. Subsequently, six machine learning models were developed and evaluated.

The SwinUNETR segmentation model achieved a dice similarity coefficient of 0.87. For AF recurrence prediction, the fusion model demonstrated superior and robust performance in internal validation. The random forest-based fusion model achieved the highest area under the curve (AUC) of 0.81 (95% CI: 0.59–0.87). Key predictive features included NT-proBNP and texture heterogeneity features from EAT, which align with known pathophysiological mechanisms involving systemic inflammation, metabolic dysregulation, and local atrial adipose tissue remodeling.

A fusion model incorporating EAT radiomics and clinical variables effectively predicts AF recurrence after PVI, with ensemble methods showing optimal performance. This study provides a multiscale, interpretable computational tool for individualized postoperative risk stratification, highlighting the complementary role of EAT imaging biomarkers to systemic clinical factors.