# Challenges and limitations of evaluating the efficacy of music intervention for preterm infants: auditory development, methodological heterogeneity, medical complexity, parental involvement and environmental barriers

**Authors:** Vito Giordano, Ji Sun Kim, Shmuel Arnon, Angelika Berger, Christian Gold

PMC · DOI: 10.3389/fped.2026.1716416 · Frontiers in Pediatrics · 2026-02-26

## TL;DR

This paper discusses the challenges in evaluating music therapy for preterm infants in NICUs, highlighting issues like auditory development and methodological inconsistencies.

## Contribution

The paper introduces a comprehensive perspective on the barriers to evaluating music therapy efficacy for preterm infants.

## Key findings

- Limited understanding of premature auditory development hinders effective music therapy evaluation.
- Environmental acoustics and methodological inconsistencies complicate music therapy implementation.
- Parental involvement and healthcare professionals' perceptions are underappreciated factors in NICU music therapy.

## Abstract

Despite growing interest in music therapy (MT) as a supportive intervention in neonatal intensive care units (NICUs), strong evidence for its long-term efficacy remains scarce. This perspective article explores the multifaceted challenges of implementing and evaluating MT in NICUs, particularly for preterm infants. These challenges include (1) limited understanding of premature auditory development, (2) environmental acoustics, (3) methodological inconsistencies in MT delivery, and the complex medical (4) and psychosocial (5) context of the NICU. Further compounding this issue is the underappreciation of parental involvement and the perception of MT among healthcare professionals. Addressing these gaps is essential for establishing standardized, effective MT protocols tailored to this vulnerable population.

## Full-text entities

- **Diseases:** premature auditory development (MESH:D002658)

## Full text

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## Figures

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## References

42 references — full list in the complete paper: https://tomesphere.com/paper/PMC12979419/full.md

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Source: https://tomesphere.com/paper/PMC12979419