# Phase angle as an early-warning indicator of glycaemic control in adults with type 1 diabetes mellitus: a cross-sectional study

**Authors:** Lun Zhang, Jiani Zhu, Fan Yang, Tongfen Cui, Xiaoyun Xi, Luying Yang, Ji-Gan Wang, Yunying Cai

PMC · DOI: 10.3389/fendo.2026.1793935 · Frontiers in Endocrinology · 2026-02-26

## TL;DR

This study shows that phase angle, a body composition measure, is linked to better blood sugar control in adults with type 1 diabetes.

## Contribution

Phase angle is proposed as a new early-warning clinical indicator for glycaemic control in type 1 diabetes.

## Key findings

- Phase angle showed a significant negative correlation with HbA1c levels in T1DM patients.
- The relationship remained after adjusting for age and weight in both genders.
- Phase angle may serve as a useful clinical indicator beyond body composition assessment.

## Abstract

For patients with poor glycemic control of adult type 1 diabetes mellitus (T1DM), in addition to managing blood glucose levels, it is worth exploring further as an early warning indicator of blood glucose control.

56 adults with T1DM, aged between 18 and 70 years, were included in the study. Data on body composition and laboratory indicators, including phase angle values and HbA1c levels, were collected. Statistical analysis was conducted to determine the correlation and the strength of association between the phase angle, and HbA1c levels.

Pearson’s correlation and linear regression models indicated a negative correlation between phase angle and HbA1c levels, even after controlling for age and weight in both males and females.

The results indicate a significant negative relationship between Phase angle and HbA1c levels. Beyond being a simple body composition parameter, Phase angle can be used as a clinical indicator of improved blood glucose control.

## Linked entities

- **Diseases:** type 1 diabetes mellitus (MONDO:0005147), T1DM (MONDO:0005147)

## Full-text entities

- **Diseases:** T1DM (MESH:D003922)
- **Chemicals:** blood glucose (MESH:D001786)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## References

30 references — full list in the complete paper: https://tomesphere.com/paper/PMC12979168/full.md

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Source: https://tomesphere.com/paper/PMC12979168