Hemodynamic simulation in the aortic arch under anemic, diabetic, and healthy blood flow conditions using computational fluid dynamics
Farzana Akter Tina, Hashnayne Ahmed, Hena Rani Biswas, Hafiz Muhammad Umer Farooqi, Hafiz Muhammad Umer Farooqi, Hafiz Muhammad Umer Farooqi, Hafiz Muhammad Umer Farooqi
TL;DR
This study uses computer simulations to compare blood flow in the aortic arch under anemic, diabetic, and healthy conditions, showing how blood properties affect vascular stress.
Contribution
The study introduces a computational model to analyze hemodynamic differences caused by anemic and diabetic blood conditions in the aortic arch.
Findings
Anemic blood flow showed reduced wall shear stress and low resistance, potentially impairing perfusion.
Diabetic blood flow exhibited higher viscosity and wall shear stress, linked to vascular stiffening and remodeling risk.
Healthy blood maintained balanced hemodynamics within normal physiological ranges.
Abstract
This study examines the hemodynamic impact of anemic, diabetic, and healthy blood conditions in the human aortic arch using computational modeling. Blood rheology was represented by the shear-thinning Carreau–Yasuda model, and simulations were carried out in a patient-inspired aortic geometry under pulsatile flow. Velocity fields, pressure gradients, and wall shear stress (WSS) distributions were quantified to assess how altered hematocrit and viscosity affect vascular loading. Anemic blood, characterized by low viscosity, showed smooth low-resistance flow with reduced WSS, potentially limiting endothelial stimulation and impairing perfusion. Diabetic blood exhibited elevated viscosity and hematocrit, producing higher flow resistance, increased WSS, and disturbed secondary flows, consistent with vascular stiffening and remodeling risk. Healthy cases maintained balanced hemodynamics…
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Taxonomy
TopicsBlood properties and coagulation · Coronary Interventions and Diagnostics · Aortic Disease and Treatment Approaches