APTES-functionalized Gd0.18Fe2.82O4@SiO2 nanocarrier for magnetothermal-triggered doxorubicin release
Pham Hoai Linh, Tran Thi Huong, Nguyen Hong Nhung, Tran Thi Ngoc Nha, Pham Thanh Phong
TL;DR
Researchers developed a magnetic and pH-responsive nanoparticle system to control the release of doxorubicin, a cancer drug, showing potential for targeted cancer treatment.
Contribution
The novel contribution is a dual-responsive (pH and magnetic field) drug delivery system using APTES-functionalized Gd0.18Fe2.82O4@SiO2 nanoparticles for controlled doxorubicin release.
Findings
The system achieved 82.6% doxorubicin loading efficiency at pH 7.4 with pH-dependent release behavior.
Magnetic field-induced heating enhanced drug release and caused over 90% cell viability loss at 55°C within 10 minutes.
The unloaded carrier showed negligible toxicity, while DOX-loaded nanoparticles exhibited concentration-dependent cytotoxicity in cancer cells.
Abstract
Externally regulated and stimuli-responsive drug delivery systems remain of significant interest for improving the controllability of cancer treatment strategies. In this study, APTES-functionalized Gd0.18Fe2.82O4@SiO2 core–shell nanoparticles were developed as a pH- and magnetically responsive platform for doxorubicin (DOX) delivery. Structural and morphological characterization confirmed quasi-spherical nanoparticles with mesoporous silica shells and satisfactory colloidal stability under physiological conditions. FTIR analysis indicated successful DOX adsorption mediated by electrostatic interactions and hydrogen bonding with amino-functionalized surfaces. The system achieved a DOX loading efficiency of 82.6% at pH 7.4, and adsorption kinetics followed a pseudo-second-order model. In vitro release studies demonstrated pronounced pH-dependent behavior, with enhanced drug release under…
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Taxonomy
TopicsNanoparticle-Based Drug Delivery · Magnetic Properties and Synthesis of Ferrites · Nanoplatforms for cancer theranostics