Challenging the citrate challenge: why we need global criteria to define citrate accumulation

Mattia M. Müller; Sascha David

PMC · DOI:10.1186/s13054-026-05941-x·March 10, 2026

Challenging the citrate challenge: why we need global criteria to define citrate accumulation

Mattia M. Müller, Sascha David

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Abstract

Linked entities

Genes, proteins, chemicals, diseases, species, mutations and cell lines named across the full text — each resolved to its canonical identifier and authoritative record.

Species1

Homo sapiens(human · species)

Chemicals5

calcium citrate tCa lactate CKRT

Diseases7

CA liver dysfunction CKRT bleeding metabolic acidosis critically ill metabolic disturbances

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Taxonomy

TopicsRenal function and acid-base balance · Extraction and Separation Processes · Phosphorus and nutrient management