Synergistic Effects of Compound Dendrobium Candidum and Antihypertensive Medications on Refractory Hypertension in Spontaneously Hypertensive Rats
Xiaoyu Chen, Cheng Tong, Jie Wang, Yue Wu, Tuo Feng, Jing Wang, Zedong Gong, Yingzhi Chen, Shiyong Chen, Xiaoming Jin, Sisi Chen, Zhongxiu Guo, Xuan Chen, Zeming Ren, Guanhai Dai, Yeling Tong, Xiyu Mei, Renzhao Wu, Xiaomin Xue
TL;DR
This study shows that combining a herbal compound with blood pressure medications can effectively treat hard-to-control hypertension in rats.
Contribution
The study introduces a novel synergistic treatment for refractory hypertension using a herbal compound and conventional drugs.
Findings
CDC combined with antihypertensive drugs achieved 100% blood pressure target success in refractory hypertensive rats.
CDC reduced the compensatory increase in AT1R and AT2R levels caused by antihypertensive drugs.
CDC treatment lowered mRNA and protein expression of AT1R and AT2R in glomerular endothelial cells.
Abstract
Compound dendrobium candidum (CDC) is formulated from Dendrobium candidum and fragrant peony. Preliminary studies have demonstrated that the combination of CDC with conventional antihypertensive medications exhibits significant synergistic effects in lowering blood pressure. The objective of this study was to evaluate the synergistic effect of combining CDC with antihypertensive medications on refractory hypertension in spontaneously hypertensive rats (SHRs) and to elucidate the underlying mechanisms involved. SHRs were treated with either CDC alone or CDC combined with two or three antihypertensive agents including irbesartan, amlodipine, or terazosin, for a duration of 6 weeks. The alterations in blood pressure, angiotensin II (Ang II), insulin, blood sugar, angiotensin II type I receptor (AT1R), angiotensin II type II receptor (AT2R), insulin receptor, insulin α receptor, and…
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Taxonomy
TopicsBiological and pharmacological studies of plants · Traditional Chinese Medicine Analysis · Phytochemistry and Biological Activities