# Glucagon-Like Peptide-1 Receptor Agonist Switching and Treatment Persistence in Adults Without Diabetes

**Authors:** Luyu Xie, Diego Anazco, Azucena Herrera Chancay, M. Sunil Mathew, Jackson M. Francis, Jaime P. Almandoz, Sarah E. Messiah

PMC · DOI: 10.1001/jamanetworkopen.2026.1272 · 2026-03-10

## TL;DR

This study examines how often people without diabetes switch GLP-1 receptor agonists and how long they stick with the treatment.

## Contribution

The study provides new insights into treatment persistence and switching behaviors of GLP-1 receptor agonists in non-diabetic adults.

## Key findings

- Switching between GLP-1 receptor agonists is common within 12 months of treatment initiation.
- Treatment persistence rates vary significantly depending on the initial GLP-1 receptor agonist prescribed.

## Abstract

This cohort study evaluates glucagon-like peptide-1 (GLP-1) receptor agonist switching patterns and 12-month adherence and persistence among adults with overweight or obesity without diabetes.

## Full-text entities

- **Genes:** GLP1R (glucagon like peptide 1 receptor) [NCBI Gene 2740] {aka GLP-1, GLP-1-R, GLP-1R}
- **Diseases:** depression (MESH:D003866), sleep apnea (MESH:D012891), gastroesophageal reflux (MESH:D005764), steatotic liver disease (MESH:D008107), Diabetes (MESH:D003920), asthma (MESH:D001249), obesity (MESH:D009765), overweight (MESH:D050177), metabolic dysfunction (MESH:D008659)
- **Chemicals:** GLP-1RA (-)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC12976791/full.md

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Source: https://tomesphere.com/paper/PMC12976791