# Clinical Efficacy Study of 755 nm Picosecond Laser Combined With 595 nm Pulsed Dye Laser in the Treatment of Port‐Wine Stain

## TL;DR

Combining two laser treatments improves the appearance of port-wine stains more effectively than using one laser alone.

## Contribution

A new combination laser therapy for port-wine stains is shown to be more effective than standard treatment.

## Key findings

- The combined laser treatment improved visual scores, lesion clearance, and vascular changes significantly.
- Patient satisfaction was higher with the combination therapy compared to PDL alone.
- Both treatments had similar safety profiles with no major adverse events.

## Abstract

Port‐wine stain (PWS) is a disfiguring vascular anomaly characterized by persistent cutaneous erythema and progressive tissue hyperplasia. Although pulsed dye laser (PDL) is the first‐line treatment and alleviates certain clinical manifestations, incomplete lesion clearance and high recurrence rates persist in some patients, posing significant therapeutic challenges.

To evaluate the efficacy and safety of sequential therapy with a 755 nm picosecond laser (PSL) combined with 595 nm PDL versus 595 nm PDL alone in treating PWS.

Thirty‐four patients with PWS were enrolled. Lesions were randomly divided into paired subregions (PDL and PDL + PSL) using a subregional control design. Efficacy was assessed through objective and subjective measures: standardized clinical and dermoscopic images were used to quantify visual scores and clearance rates; reflectance confocal microscopy (RCM) quantitatively analyzed changes in vascular density and diameter; patient satisfaction and adverse reactions were also evaluated.

The PSL + PDL group showed significantly greater improvement in visual assessment scores, lesion area clearance, vascular density, vascular diameter, and patient satisfaction compared to the PDL group (all p < 0.05). While no statistically significant difference was observed in adverse event incidence rates between the two treatment modalities (p > 0.05), both regimens exhibited favorable safety profiles.

The PSL + PDL regimen shows significantly superior efficacy over PDL alone, thus presenting a promising and advanced therapeutic alternative for PWS treatment.