# Pharyngeal electrical stimulation for postextubation dysphagia after stroke: a randomized trial on hospitalization costs from a health insurance perspective

**Authors:** Bendix Labeit, Anne Jung, Jonas von Itter, Inga Claus, Sigrid Ahring, Tobias Warnecke, Paul Muhle, Almut Kremer, Sven G. Meuth, Rainer Dziewas, Sonja Suntrup-Krueger

PMC · DOI: 10.1038/s41598-026-43591-9 · 2026-03-09

## TL;DR

This study explores whether pharyngeal electrical stimulation reduces hospital costs for stroke patients with swallowing difficulties, but finds no significant difference in average costs.

## Contribution

The study provides early evidence on the potential cost impact of pharyngeal electrical stimulation for post-stroke dysphagia from a health insurance perspective.

## Key findings

- Mean hospital costs were lower in the PES group but not statistically significant.
- Three high-cost outliers occurred only in the sham group.
- Results suggest a need for larger studies to confirm cost-effectiveness.

## Abstract

Dysphagia is a frequent and serious complication after stroke, associated with pneumonia, malnutrition, prolonged intensive care unit stay, and higher healthcare costs. Pharyngeal electrical stimulation (PES) is a novel therapy that may support recovery from postextubation dysphagia. This study assessed the cost-effectiveness of PES in stroke patients from a health insurance perspective. We performed a secondary analysis of a randomized controlled trial including 60 stroke patients with postextubation dysphagia, randomized to PES (n = 30) or sham stimulation (n = 30). Sham treatment involved identical device placement without stimulation. Acute hospital costs were estimated per patient using the 2025 German Diagnosis-Related Groups (DRG) reimbursement system. Mean costs were compared between groups with a one-sided t-test, and distributions were explored with boxplots. Mean DRG costs per patient were €22,392.89 (SD = €14,980.84) in the sham group and €18,127.20 (SD = €7,828.65) in the PES group. The difference was not statistically significant (p = 0.087). However, three outliers with costs >€50,593 occurred in the sham group, compared with none in the PES group (maximum €35,257.49). Although the difference in mean hospitalization costs between groups was not statistically significant, extreme high-cost outliers occurred only in the sham group in this pilot sample. This observation is exploratory and hypothesis-generating and requires confirmation in larger, adequately powered health-economic studies before firm conclusions regarding cost-effectiveness can be drawn.

## Linked entities

- **Diseases:** stroke (MONDO:0005098), pneumonia (MONDO:0005249), malnutrition (MONDO:0006873)

## Full-text entities

- **Diseases:** Infections (MESH:D007239), ischemic stroke (MESH:D002544), cough (MESH:D003371), Dysphagia (MESH:D003680), malnutrition (MESH:D044342), ischemic or hemorrhagic stroke (MESH:D002543), Multiple Sclerosis (MESH:D009103), Muscular Dystrophy (MESH:D009136), diseases and disorders of the nervous system (MESH:D009422), aspiration (MESH:D011015), Dementia (MESH:D003704), Alzheimer (MESH:D000544), sensory deficits (MESH:D012678), pulmonary complications (MESH:D008171), hemorrhagic stroke (MESH:D000083302), respiratory infections (MESH:D012141), inflammation of (MESH:D007249), respiratory complications (MESH:D012140), Ventilation (MESH:D053717), respiratory organs (MESH:D012131), BL (MESH:D002051), Stroke (MESH:D020521), pneumonia (MESH:D011014)
- **Chemicals:** PES (-)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12976082/full.md

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Source: https://tomesphere.com/paper/PMC12976082