# Obesity and long bone fractures in children. Systematic review

**Authors:** Ahmed Aly, Tarek Aly

PMC · DOI: 10.1007/s00402-026-06221-7 · 2026-03-10

## TL;DR

This review finds that childhood obesity increases the risk and complexity of long bone fractures and affects treatment outcomes.

## Contribution

The study systematically evaluates how obesity influences fracture patterns and treatment outcomes in children.

## Key findings

- Overweight and obese children have higher odds of lower extremity fractures like tibia and femur fractures.
- Obesity is linked to more complex fracture patterns and higher failure rates of nonsurgical treatments.
- Operative complications are more frequent in obese children, but long-term outcomes are similar to non-obese groups.

## Abstract

Childhood obesity is a pressing global health issue with potential implications for musculoskeletal injury risk and recovery. Although the influence of obesity on bone metabolism is acknowledged, its specific connection to the incidence, patterns, and treatment results of long bone fractures in the pediatric demographic requires further clarification.

This systematic review aims to evaluate the existing literature on the relationship between obesity and long bone fractures in children and adolescents, with a focus on fracture risk, anatomical distribution, management approaches, and clinical outcomes.

We conducted a systematic literature search of PubMed, MEDLINE, Cochrane Library, and Google Scholar for studies published from January 2000 to March 2025. Search terms included “childhood obesity”, “bone health”, and “long bone fractures”. We included English-language original research that analyzed the relationship between pediatric obesity (BMI ≥ 95th percentile) and long bone fractures. Data on study characteristics, fracture patterns, treatments, and outcomes were extracted.

Out of 2,152 articles screened, 14 met the inclusion criteria. Children who were overweight or obese had higher odds of lower extremity fractures, particularly of the tibia and femur (odds ratios 1.5–3.3). Obesity was linked to more complex fracture patterns, including physical involvement and displacement, and a higher failure rate of nonsurgical management, especially for forearm and supracondylar fractures. Operative complications, such as varus deformity and pin-related issues, were more frequent in obese patients. However, no consistent differences were observed between obese and non-obese groups regarding mortality and long-term functional outcomes.

Pediatric obesity significantly elevates the risk and complexity of long bone fractures and complicates both nonoperative and surgical management. Acknowledging these challenges is crucial for optimizing treatment and preventing adverse outcomes. Further multicenter prospective studies are needed to clarify the underlying biomechanical and metabolic mechanisms and to guide the development of individualized management protocols.

Systematic Review, Level III.

## Linked entities

- **Diseases:** obesity (MONDO:0011122)

## Full-text entities

- **Genes:** LEP (leptin) [NCBI Gene 3952] {aka LEPD, OB, OBS}, TNFRSF11B (TNF receptor superfamily member 11b) [NCBI Gene 4982] {aka OCIF, OPG, PDB5, TR1}, TNFSF11 (TNF superfamily member 11) [NCBI Gene 8600] {aka CD254, ODF, OPGL, OPTB2, RANKL, TNLG6B}, INS (insulin) [NCBI Gene 3630] {aka IDDM, IDDM1, IDDM2, ILPR, IRDN, MODY10}, TNF (tumor necrosis factor) [NCBI Gene 7124] {aka DIF, IMD127, TNF-alpha, TNFA, TNFSF2, TNLG1F}, IL6 (interleukin 6) [NCBI Gene 3569] {aka BSF-2, BSF2, CDF, HGF, HSF, IFN-beta-2}
- **Diseases:** bone fragility (MESH:C536063), femoral fractures (MESH:D005264), nerve palsies (MESH:D003389), Blount disease (MESH:C536237), tibia fracture (MESH:C535563), gait instability (MESH:D043171), leg fractures (MESH:D010264), metabolic (MESH:D008659), Salter-Harris type II fractures (MESH:D000072042), vitamin D deficiency (MESH:D014808), Overweight (MESH:D050177), postoperative (MESH:D019106), Obese (MESH:D009765), varus malalignment (MESH:D017760), metabolic bone diseases (MESH:D001851), musculoskeletal injury (MESH:D009140), underweight (MESH:D013851), fatty liver disease (MESH:D005234), distal humeral fractures (MESH:D000092483), type 2 diabetes (MESH:D003924), insulin resistance (MESH:D007333), femoral and tibial fractures (MESH:D013978), articular fractures (MESH:D057072), impaired bone health (MESH:D001847), femur (MESH:D000092524), lower extremity fractures (MESH:D010291), bone weakness (MESH:D018908), slipped capital femoral epiphysis (MESH:D060048), infection (MESH:D007239), Lower Limb Fractures (MESH:D038061), forearm and supracondylar fractures (MESH:D000092503), hyperinsulinemia (MESH:D006946), Upper Limb Fractures (MESH:D038062), ESIN (MESH:D009260), varus angulation (MESH:D060905), Fracture (MESH:D050723), metabolic syndrome (MESH:D024821), humerus fracture (MESH:D006810), complication (MESH:D008107), inflammation (MESH:D007249), injuries (MESH:D014947)
- **Chemicals:** ceramides (MESH:D002518), diacylglycerol (MESH:D004075), free fatty acids (MESH:D005230)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

8 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12975796/full.md

---
Source: https://tomesphere.com/paper/PMC12975796