Evaluation of a 10% Urea Lotion for Xerosis: Clinical and Patient‐Reported Outcomes From a Prospective Study

TL;DR

A 10% urea lotion significantly improved dry skin symptoms and quality of life in a 60-day study with no adverse effects.

Contribution

Demonstrates the clinical efficacy and high patient satisfaction of a 10% urea lotion for treating xerosis.

Findings

Skin hydration and elasticity improved by over 50% after 60 days of use.

Participants reported significant reductions in redness, scaling, and itching.

Quality of life improved by 61% as measured by the Skindex-16 scale.

Abstract

Xerosis cutis is a common skin condition characterized by dryness, scaling, and pruritus due to impaired barrier function and reduced natural moisturizing factors. This study aimed to evaluate the clinical efficacy of a 10% urea lotion in adults with xerosis and assess participant satisfaction with the product.

A prospective, single‐arm clinical study was conducted over 60 days in adults with confirmed xerosis. Participants applied a 10% urea lotion with Prolom thermal water twice daily. Skin hydration and elasticity were measured by corneometry and cutometry at baseline, day 14, day 30, and day 60. Subjective outcomes were assessed using a product satisfaction questionnaire and the Skindex‐16 scale. Data were analyzed using repeated measures ANOVA with p < 0.05 considered significant.

Significant improvements were observed in skin hydration (+55.3%) and elasticity (+55%), as well as reductions in redness, scaling, and itching (all p < 0.001). Skindex‐16 total scores improved by 61%, reflecting enhanced quality of life. The lotion was well tolerated, with no significant adverse effects, and participants reported high satisfaction and willingness to continue use.

The 10% urea lotion with Prolom thermal water demonstrated significant clinical efficacy in improving hydration, elasticity, and overall skin condition in adults with xerosis over a 60‐day period. The treatment was well tolerated and associated with high patient satisfaction and a marked improvement in quality of life.