Adherence to plant-based diet and risk of heart failure among middle-aged and older population

TL;DR

Eating a healthy plant-based diet may lower heart failure risk in middle-aged and older adults.

Contribution

This study is among the first to link healthful and unhealthful plant-based diets with heart failure risk in a large UK population.

Findings

Higher healthful plant-based diet index was linked to 16% lower heart failure risk.

Unhealthful plant-based diet index was linked to 11% higher heart failure risk.

Overall plant-based diet showed no significant association with heart failure.

Abstract

Plant-based diets have been demonstrated to be associated with lower risk of several chronic diseases. However, a comprehensive assessment of plant-based diet quality and its association with heart failure (HF) is limited. This study aimed to investigate whether healthful and unhealthful plant-based dietary patterns are associated with overall HF risk among middle-aged and older adults in the United Kingdom.

We included a total of 190,092 UK Biobank participants without HF at baseline. Three plant-based diet indices were calculated using 24-h dietary recalls based on 17 food groups: the overall plant-based diet index (PDI), healthful plant-based diet index (hPDI), and unhealthful plant-based diet index (uPDI). Multivariable Cox regression models were applied to assess the association between these indices and incident HF.

Over a median follow-up of 13.04 years, 4,351 cases of new-onset HF were recorded. Compared to the lowest tertile, the multivariable-adjusted hazard ratios (HRs) with 95% confidence interval (CI) for HF in the highest tertile were 0.94 (0.88–1.02) for overall PDI, 0.84 (0.78–0.91) for hPDI, and 1.11 (1.03–1.19) for uPDI.

A higher intake of healthful plant-based diets was associated with a lower risk of HF, while follow unhealthful plant-based diet was linked to a higher overall HF risk. Adhering to a high-quality diet primarily based on healthy plant-based foods may be helpful prevent HF.

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