A case of solitary bone plasmacytoma to multiple myeloma: a case report
Zhimin Fang, Zhong Tian, Jiyang Tang, Bo Lei, Zhongcong He, Cheng Zhu, Huangyu Luo, Ni Fu, Yuguang Shen
TL;DR
A patient with a rare rib tumor initially diagnosed as a benign condition later developed multiple myeloma after refusing recommended treatment.
Contribution
This case highlights the progression from solitary bone plasmacytoma to multiple myeloma and the importance of adjuvant therapy.
Findings
The initial diagnosis of fibrous/osteofibrous dysplasia was incorrect; histopathology confirmed solitary bone plasmacytoma.
The patient's disease progressed to multiple myeloma 21 months after surgery due to refusal of adjuvant radiotherapy.
This case emphasizes the need for accurate diagnosis and adherence to recommended treatment for solitary bone plasmacytoma.
Abstract
Solitary bone plasmacytoma of the rib is uncommon but recognized. We report a case presenting with recurrent, predominantly nocturnal chest wall pain. Imaging revealed an expansile lesion on the left ninth rib and initially suggested fibrous/osteofibrous dysplasia. The patient underwent resection of the involved rib segment. Histopathology and immunohistochemistry confirmed solitary bone plasmacytoma. The patient declined the recommended adjuvant radiotherapy. Twenty-one months later, the disease progressed to multiple myeloma.
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Taxonomy
TopicsMultiple Myeloma Research and Treatments · Management of metastatic bone disease · Myeloproliferative Neoplasms: Diagnosis and Treatment