Phenotyping of Fontan‐Associated Renal Physiology and Disease

TL;DR

This study explores kidney function and injury in Fontan patients, revealing progressive decline and altered blood flow patterns compared to healthy individuals.

Contribution

The study introduces a comprehensive phenotyping approach to identify and characterize Fontan-Associated Renal Disease (FARD).

Findings

Fontan patients show lower cystatin C-based eGFR and higher urine albumin excretion compared to controls.

Intrarenal venous and arterial compliance is reduced in Fontan patients, indicated by higher impedance and resistance indices.

Kidney function decline in Fontan patients correlates with age more strongly than in healthy individuals.

Abstract

Kidney dysfunction is prevalent but insufficiently understood in Fontan patients. We aimed to investigate Fontan‐Associated Renal Disease (FARD) through comprehensive phenotyping using biomarkers of renal function and injury, as well as ultrasound assessment of intrarenal hemodynamics.

We prospectively collected data on serum creatinine and cystatin C levels, and 24‐h urine creatinine clearance and albumin excretion in 25 Fontan patients, comparing them to healthy age‐ and sex‐matched controls. Additionally, we measured intrarenal venous and arterial flow patterns using Doppler ultrasonography.

Median age was 28 (Q1–Q3: 19–35) years, with 48% female. Compared to controls, Fontan patients had similar creatinine‐based eGFR (eGFRcr) (114 vs. 106 mL/min/1.73 m2; p = 0.2), lower cystatin C‐based eGFR (eGFRcys) (96 vs. 106 mL/min/1.73 m2; p = 0.045), and lower 24‐h urinary creatinine excretion (10.0 vs. 13.7 mmol/24 h; p < 0.001). Additionally, patients had higher 24‐h urine albumin excretion (14 vs. 2 mg/24‐h; p < 0.001). In patients, both eGFRcys and urine albumin correlated with age (r = −0.56 and r = 0.44, respectively; p < 0.05). Twenty‐‐four out of 25 patients and all controls had continuous intrarenal venous flow patterns. Venous impedance and arterial renal resistance indices were higher in patients than controls (0.44 vs. 0.14 and 0.67 vs. 0.60, respectively; p < 0.05).

FARD involves a progressive decline in kidney function and glomerular injury. eGFRcr masks kidney dysfunction in Fontan patients due to reduced muscle mass. Fontan intrarenal hemodynamics demonstrate decreased venous and arterial compliance. Moreover, continuous intrarenal venous flow persists in Fontan patients.

In patients with a Fontan circulation, both kidney function and glomerular injury progressively decline with age, with a stronger decline than in healthy individuals. Additionally, intrarenal haemodynamics in patients with a Fontan circulation demonstrate decreased venous and arterial compliance, evident through elevated venous impedance and renal resistance indices.

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