# A Case Series of Lymphangioleiomyomatosis, a Rare Cystic Lung Disease

## TL;DR

This paper reports five cases of a rare lung disease called LAM, highlighting its symptoms and the importance of early diagnosis.

## Contribution

The study contributes by identifying five new LAM cases in a short period, suggesting potential underdiagnosis.

## Key findings

- All five patients were women aged 40–54 with symptoms like dyspnea and cough.
- HRCT scans showed characteristic thin-walled air cysts in all cases.
- Three cases were confirmed histopathologically, emphasizing the need for awareness of LAM's features.

## Abstract

Lymphangioleiomyomatosis (LAM) is a rare interstitial lung disease that predominantly affects women of childbearing age. In this case series, we presented five cases diagnosed with LAM in our clinic in the last 2 years. All cases were female, and their ages ranged from 40 to 54 years. The primary symptoms of LAM seen in the cases were exertional dyspnea and cough. Radiological examination revealed multiple bilateral thin‐walled air cysts on high‐resolution computed tomography (HRCT) in all cases. In three cases, the diagnosis of LAM was made histopathologically by wedge resection. Awareness of this rare disease's clinical and radiological features is critical for early diagnosis and timely initiation of treatment.

We studied five women with a rare lung condition called LAM that typically affects only 1–5 women per 10 million. All patients had breathing difficulties and characteristic lung scans showing multiple thin‐walled air sacs. Finding five cases at one center in just 2 years suggests this condition might be more common than previously thought or often goes undiagnosed. Earlier recognition by doctors could help patients receive appropriate treatment sooner, potentially improving their quality of life.