# Why Did Treg and Immune Tolerance Win Nobel Prize This Year?

**Authors:** Song Guo Zheng (郑颂国)

PMC · DOI: 10.1093/gpbjnl/qzaf124 · 2025-12-12

## Full-text entities

- **Genes:** FOXP3 (forkhead box P3) [NCBI Gene 50943] {aka AIID, DIETER, IPEX, JM2, PIDX, XPID}, Ptprc (protein tyrosine phosphatase receptor type C) [NCBI Gene 19264] {aka B220, CD45R, Cd45, L-CA, Ly-5, Lyt-4}, Foxp3 (forkhead box P3) [NCBI Gene 20371] {aka JM2, scurfin, sf}, Il2ra (interleukin 2 receptor, alpha chain) [NCBI Gene 16184] {aka CD25, Il2r, Ly-43}, Il6 (interleukin 6) [NCBI Gene 16193] {aka Il-6}, Cd28 (CD28 antigen) [NCBI Gene 12487], Cd4 (CD4 antigen) [NCBI Gene 12504] {aka L3T4, Ly-4}
- **Diseases:** autoimmune and inflammatory diseases (MESH:D001327), enteropathy (MESH:C538273), immune dysregulation (OMIM:614878), polyendocrinopathy (MESH:D016884), X-linked (IPEX) Syndrome (MESH:C580192), autoimmune inflammatory reactions (MESH:D007249), cancer (MESH:D009369), GvHD (MESH:D006086)
- **Chemicals:** all-trans retinoic acid (MESH:D014212)
- **Species:** Mus musculus (house mouse, species) [taxon 10090], Homo sapiens (human, species) [taxon 9606]

## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC12974991/full.md

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Source: https://tomesphere.com/paper/PMC12974991