# Association between the atherogenic index of plasma and acute kidney injury in sepsis patients

## TL;DR

This study shows that higher atherogenic index of plasma is linked to increased risk of acute kidney injury in sepsis patients.

## Contribution

The study is the first to demonstrate a positive linear association between AIP and AKI risk in septic patients.

## Key findings

- Each 0.1-unit increase in AIP was associated with a 10% higher risk of AKI.
- The association remained significant after excluding patients with renal infections.
- No significant interactions were found across various subgroups like age, gender, and comorbidities.

## Abstract

Although metabolic abnormalities are directly linked to acute kidney injury (AKI) in septic patients, the function of the atherogenic index of plasma (AIP) is yet unknown.

This study examined the relationship between AIP and AKI risk in septic patients, providing insight into the role of lipid metabolism in renal injury.

This study investigated patients with sepsis using data from the eICU Collaborative Research Database (eICU-CRD). The AIP was calculated as the base-10 logarithm of the ratio of triglycerides to high-density lipoprotein cholesterol. We employed multivariate logistic regression to evaluate the association between AIP and AKI. Potential nonlinear relationships were assessed using restricted cubic spline (RCS) curve modeling. Additionally, subgroup and sensitivity analyses were conducted to assess the robustness of these findings.

The median age of the 771 patients was 66.6 years, with 173 (22.4%) developing AKI. A positive linear association was observed between the AIP and the risk of AKI. Specifically, each 0.1-unit increase in AIP was associated with a 10% higher risk of AKI (OR = 1.10, 95% CI: 1.05–1.15, P < 0.001). Sensitivity analyses after excluding patients with renal infections showed that AIP remained associated with the risk of acute kidney injury. Stratified analyses showed no significant interactions (all P for interaction > 0.05) in gender, age, BMI, SOFA score, GCS score, presence of other diseases (diabetes mellitus, chronic obstructive pulmonary disease, congestive heart failure).

For septic patients, the relationship between AIP and risk of AKI was positively linear, with higher AIP indicating higher risk of AKI.