MicroRNAs miR-29a-3p and miR-192-5p: promising urinary biomarkers for kidney function loss

TL;DR

This study found that two microRNAs in urine could help detect kidney damage in people with type 1 diabetes.

Contribution

Identified miR-29a-3p and miR-192-5p as potential urinary biomarkers for diabetic kidney disease.

Findings

miR-29a-3p levels were higher in patients with diabetic kidney disease (DKD) and correlated with kidney function decline.

miR-192-5p levels were elevated in moderate DKD and also correlated with worsening kidney function.

Abstract

This study aimed to evaluate the expression of miR-29a-3p and miR-192-5p in
patients with type 1 diabetes mellitus (T1DM) with diabetic kidney disease
(DKD) compared to those without DKD.

This study included 29 patients with T1DM, comprising 13 without DKD (non-DKD
group) and 16 with DKD, who were further subdivided into nine patients with
moderate DKD and seven with severe DKD. MiR-29a-3p and miR-192-5p expression
levels were measured in urine samples using qPCR and are presented as
medians (25-75th percentiles).

miR-29a-3p levels were higher in patients with DKD compared to the non-DKD
group [1.24 (0.97-1.74) versus 0.83 (0.72-0.99); P = 0.008]. Its expression
showed a negative correlation with estimated glomerular filtration rate
(eGFR) (P = 0.007) and a positive correlation with creatinine levels (P =
0.004). MiR-192-5p levels were higher in patients with moderate DKD compared
to the non-DKD group [2.15 (1.45-4.21) versus vs. 1.42 (0.98-2.45); P =
0.015], showing a negative correlation with eGFR (P = 0.003) and a positive
correlation with creatinine (P = 0.006).

The differential expression of miR-29a-3p and miR-192-5p in DKD highlights
their potential as promising biomarkers for this complication.

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