# Resting Oxygen Consumption Estimates in Scleroderma Can Lead to Underestimation of Cardiac Output

## TL;DR

This study shows that estimating resting oxygen consumption in scleroderma patients can lead to incorrect cardiac output measurements.

## Contribution

The study compares prediction equations with direct measurements in systemic sclerosis patients, highlighting diagnostic inaccuracies.

## Key findings

- Prediction equations for rVO2 showed significant discrepancies compared to direct measurements in systemic sclerosis patients.
- These inaccuracies may lead to underestimation of cardiac output, affecting clinical assessments.

## Abstract

Accurate resting oxygen consumption (rVO2) quantification is critical for Fick‐derived cardiac output calculations. Yet, clinical practice predominantly uses empirical estimations, which can be inaccurate. We evaluated the established rVO₂ prediction equations against direct metabolic cart measurements in systemic sclerosis patients, revealing significant discordances with potential diagnostic implications.