# A Direct Current-to-Digital Converter IC for Luminescence-Based Detection Toward an Energy Efficient Transcutaneous Carbon Dioxide Sensor Wearable

**Authors:** TUNA B. TUFAN, BENJAMIN LARKIN, JOHN McNEILL, ULKUHAN GULER

PMC · DOI: 10.1109/ojsscs.2025.3646593 · 2026-03-11

## TL;DR

This paper introduces a new energy-efficient wearable sensor for noninvasive carbon dioxide monitoring using a novel integrated circuit design.

## Contribution

The paper presents the first integrated circuit implementation of a ratiometric time-domain dual lifetime referencing technique for energy-efficient wearables.

## Key findings

- The proposed design achieves 0.15-nA/cnt resolution with 88-μW power consumption.
- The system maintains a luminescence ratio error of ≤0.5% across a wide input range using an I-DAC current-scaling technique.

## Abstract

Continuous monitoring of arterial carbon dioxide is critical for assessing respiratory function and detecting ventilation inefficiencies. Arterial blood gas analysis, the clinical gold standard, is invasive and limited to intermittent measurements in hospital settings. Transcutaneous carbon dioxide sensing offers a noninvasive alternative by measuring carbon dioxide diffusing through the skin, which strongly correlates with arterial carbon dioxide. However, conventional transcutaneous sensors require bulky bedside monitors and heating elements, making them unsuitable for wearable applications. This work presents the first integrated circuit implementation of a ratiometric time-domain dual lifetime referencing technique using a direct current-to-digital converter architecture designed for energy-efficient wearables. The proposed design achieves 0.15-nA/cnt resolution over a 30-μA input range at 88-μW power consumption. With the proposed I-DAC current-scaling technique, the system maintains a luminescence ratio error of ≤0.5% across a wide input range.

## Full-text entities

- **Genes:** CCNG1 (cyclin G1) [NCBI Gene 900] {aka CCNG}, CPD (carboxypeptidase D) [NCBI Gene 1362] {aka GP180}, SLC28A1 (solute carrier family 28 member 1) [NCBI Gene 9154] {aka CNT1, HCNT1, URCTU}, SLC28A2 (solute carrier family 28 member 2) [NCBI Gene 9153] {aka CNT2, HCNT2, HsT17153, SPNT1}
- **Diseases:** CHARGE (MESH:D058747), SYSTEM (MESH:D015619), COPD (MESH:D029424), DIRECT (MESH:D051556), respiratory depression (MESH:D012131), hyperventilation (MESH:D006985), NOISE (MESH:D014012), SCALING I (MESH:C538175), DIGITAL (MESH:C000721267)
- **Chemicals:** PO2 (MESH:C093415), PO1 (MESH:C093414), StrongArm (MESH:C415325), I- (MESH:D007455), CO2 (MESH:D002245), N2 (MESH:D009584), O2 (MESH:D010100), CDC (-)
- **Species:** Homo sapiens (human, species) [taxon 9606]
- **Mutations:** M, C-44  C

## Figures

13 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12974256/full.md

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Source: https://tomesphere.com/paper/PMC12974256