DOX-conjugated unimolecular micelles from benzaldehyde-functionalized star copolymer via metal-free ATRP for pH-responsive drug delivery
Wei Ma, Hongyan Yang, Xinyue Ma, Jiao Huang, Li Chen, Atsushi Takahara
TL;DR
A new method creates stable, pH-sensitive drug carriers using a metal-free process, improving drug delivery efficiency and sustainability.
Contribution
A metal-free ATRP strategy for synthesizing DOX-conjugated star copolymers with pH-responsive drug release.
Findings
The star copolymer forms stable unimolecular micelles with high colloidal stability.
The system shows pH-triggered drug release under acidic conditions.
In vitro tests show effective cellular uptake and cytotoxicity against H460 lung cancer cells.
Abstract
The development of polymer prodrugs with well-defined architectures capable of forming stable nanomicelles is important for achieving precise and efficient drug delivery. Compared with conventional linear systems, star-shaped copolymer prodrugs offer enhanced micellar stability owing to their covalently tethered architecture. However, many existing synthetic approaches rely on transition-metal catalyzed polymerization and customized monomers, which limit their sustainability and practical applicability. Herein, we report a pH-responsive doxorubicin (DOX)-conjugated benzaldehyde-functionalized star-shaped copolymer synthesized via an environmentally benign metal-free atom transfer radical polymerization (ATRP) strategy. A hydroxyl-functionalized star-shaped copolymer scaffold was first prepared from readily available monomers and subsequently modified to introduce pendant benzaldehyde…
Genes, proteins, chemicals, diseases, species, mutations and cell lines named across the full text — each resolved to its canonical identifier and authoritative record.
Click any figure to enlarge with its caption.
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Figure 6
Figure 7
Figure 8
Figure 9
Figure 10
Figure 11
Figure 12
Figure 13
Figure 14
Figure 15
Figure 16
Figure 17
Figure 18Peer Reviews
No public reviews on file for this paper yet. If you reviewed it on a platform where reviews are public (OpenReview, ICLR, NeurIPS, ICML), you can paste yours below so the community can read it here.
Videos
No videos yet. Explain this paper in a talk, walkthrough, or lecture? Add one.
Taxonomy
TopicsAdvanced Polymer Synthesis and Characterization · Nanoparticle-Based Drug Delivery · Hydrogels: synthesis, properties, applications