Causal Association of Circulating Adipokines With the Risk of Carpal Tunnel Syndrome and Diabetic Neuropathy: A Bidirectional Two‐Sample Mendelian Randomization Study
Hongquan Wen, Zhiqiang Fan, Pengfei Wang, Jia Li
TL;DR
This study found no strong evidence that certain fat-related proteins cause carpal tunnel syndrome or diabetic neuropathy.
Contribution
The study used genetic data to investigate causal links between adipokines and two neuropathies for the first time.
Findings
No significant causal associations were found between adiponectin, leptin, resistin, or IL-6 and carpal tunnel syndrome.
No significant causal associations were found between these adipokines and diabetic neuropathy.
Results suggest that confounders like obesity and hyperglycemia may influence the observed relationships.
Abstract
This study is aimed at exploring the causal association between genetically predicted serum levels of circulating adipokines and the risk of carpal tunnel syndrome (CTS) and diabetic neuropathy (DN). A two‐sample bidirectional Mendelian randomization (MR) design was employed, using the inverse‐variance weighted (IVW), weighted median, weighted mode, and MR‐Egger regression methods. Sensitivity tests included MR‐Egger, MR‐PRESSO, Cochran′s Q, and leave‐one‐out methods. A total of 52 single‐nucleotide polymorphisms (SNPs) associated with adiponectin, leptin, resistin, and IL‐6 levels were selected as instrumental variables (IVs). With adiponectin as exposure, no statistically significant causal association was confirmed for CTS (OR [95% CI]: 1.0331 [0.8257–1.2925], p = 0.776) or DN (OR [95% CI]: 0.865 [0.5385–1.3894], p = 0.549). With leptin levels as exposure, no statistically…
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Taxonomy
TopicsPeripheral Nerve Disorders · Osteoarthritis Treatment and Mechanisms · Tendon Structure and Treatment