A Histopathological Study of Induced Open Wounds Treated With Urinary Bladder Submucosa Scaffold in Rabbits
Majid A. Alkhilani, Omar Tariq Hammoodi, Ali A. Tala’a, Waleed Al-Nuaimy
TL;DR
This study shows that using a scaffold made from cow bladder tissue helps rabbit wounds heal faster than normal.
Contribution
The study demonstrates the effectiveness of decellularized urinary bladder submucosa as a scaffold for accelerating wound healing in rabbits.
Findings
Wounds treated with the ECM scaffold showed significantly faster healing starting from the seventh postwounding day.
The treated group exhibited thicker epidermal layers and fibroplasia, while the control group showed fibrosis and granulation tissue.
The ECM scaffold promoted wound contraction and improved tissue regeneration compared to the control group.
Abstract
Treating various wounds is one of the challenges that researchers are working on to find innovative ways to shorten and accelerate healing. Various materials have been used for this purpose, including those from the submucosal layer of certain animals, such as the calf bladder used in this study. Since extracellular matrix (ECM) contains many components that are important for the healing process, such as collagen, laminin, and hyaluronic acid, it has the potential to accelerate wound healing. The study used twelve adult rabbits. After surgical preparation, a 2 × 2 cm square wound was made on each side of the animal’s body behind the costal arch in the upper abdomen. The wound on the right side was washed with normal saline only as a control group, and the wound on the left side was treated with a dry decellularized ECM. Fresh urinary bladders were collected from slaughtered calves and…
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Taxonomy
TopicsTissue Engineering and Regenerative Medicine · Wound Healing and Treatments · Comparative Animal Anatomy Studies