# Research Progress on the Regulatory Mechanism of Respiratory Microbiota in the Comorbidity of Chronic Obstructive Pulmonary Disease and Lung Cancer

## TL;DR

This paper reviews how respiratory microbiota influence the co-occurrence of COPD and lung cancer, highlighting their role in inflammation and disease progression.

## Contribution

The paper systematically summarizes dynamic features of respiratory microbiota in COPD-LC comorbidity and their regulatory mechanisms.

## Key findings

- Respiratory microbiota dynamically change in COPD, LC, and their comorbidity.
- Microbiota contribute to chronic inflammation and genomic damage in COPD-LC comorbidity.
- Microbial shifts may serve as potential biomarkers for early cancer detection and disease management.

## Abstract

慢性阻塞性肺疾病（chronic obstructive pulmonary disease, COPD）与肺癌（lung carcinoma, LC）均为我国面临的重大公共卫生挑战。随着微生物检测方法的不断更新迭代，呼吸道微生物在呼吸系统疾病发生发展中的作用日益凸显。本文系统综述了COPD与LC病程中呼吸道微生物的动态特征，并探讨了其通过持续驱动慢性炎症、介导基因组损伤及参与免疫调控等机制在COPD-LC共病中发挥的关键桥梁作用，旨在深化对呼吸道微生物的认识，为优化现有治疗策略、探寻癌症早筛微生物标志物以及慢性呼吸系统疾病临床管理提供新视角。

Comparative analysis of abundance changes in core respiratory tract bacterial genera among patients with COPD, LC, and comorbid conditions